HTC, a couple of months ago confirmed that three of its smartphones will be upgraded to the latest software aka Android Oreo. These devices are HTC U11, HTC U Ultra, and HTC 10. The Taiwanese company back then said that the mentioned devices will get the Oreo update by Q4. Now a report circulating all around the internet suggests that the HTC is already in talks with Google to update all the three phones to Oreo by November. But then, the company, mentioning the roll out timeline only says Q4 and didn’t mention any month as of yet.Soon after Google announced Oreo back in the month of August it said that Pixel and Nexus phones are going to be the first ones to get the new software update. The company further mentioned that it is also in talks with other smartphone makers to upgrade some of their devices to Oreo. Google is reportedly working with Essential, General Mobile, HMD Global Home of Nokia Phones, Huawei, HTC, Kyocera, LG, Motorola, Samsung, Sharp, and Sony to bring the Oreo update to some of their devices.HTC back in August tweeted the coming of Oreo to HTC U11, HTC U Ultra, and HTC 10. The company confirmed this via a tweet where it wrote, “We’re excited to bring Android 8.0 to the HTC U11, U Ultra, & 10, beginning with U11 in Q4. Stay tuned for more Oreo details & new products!”Now a new report reveals that the Oreo roll out to all three HTC phones will happen in the upcoming month – November. This bit of information comes from a HTC leaker LlabTooFeR. According to the leaked report, HTC U11 Android Oreo update is in its final stage of development and this possibly why the company may bring the Oreo update in November.advertisementAlso Read: HTC U11 review: Sense and sensibilityMeanwhile, the Taiwanese based smartphone manufacture is planning to announce a new phone on Nov 2. HTC has already started sending out press invite for the launch event, but as of now hasn’t confirmed the name of the device. However, chances are HTC may either unveil an Android One edition of the U11 which will be called HTC U11 Life or the successor of it aka the U11 Plus.However, a new report that leaked online recently suggests that HTC will be launching the Android One edition of the HTC U11 which is the U11 Life. On the other hand, the U11 Plus is recently spotted on TENNA certification site. Going by the Chinese certification site, the smartphone – U11 Plus will come with a bezel-less display. It shows thin bezels at the top and bottom. The phone is further seen with glossy finish at the back side. The rear panel further fits the camera at the center, below which is the fingerprint sensor.Going by the specs, HTC U11 Plus is expected to feature a 6-inch WQHD+ display with an 18:9 aspect ratio and will be powered by the latest processor by Qualcomm, which is the Snapdragon 835 chipset. The Plus edition is further tipped to come in two variants, one with 4GB of RAM with 64GB of internal storage, while the second model may come with 6GB of RAM and 128GB of internal storage. In the imaging department, TENNA shows that the phone may come with a 12-megapixel rear camera along with f/1.7 aperture and dual-LED flash. While on the front the device is said to sport an 8-megapixel camera.
Pakistan pacer Mohammad Amir is a nightmare for batsmen around the world and his rivalry with Virat Kohli is now well documented. The two have a lot of mutual respect and admiration.Last year, before the Champions Trophy final between India and Pakistan in England, Amir had picked Kohli as his favourite batsman.In the final, Amir removed Kohli cheaply but not before the Indian captain had been dropped in the previous delivery. The left-arm pacer had later revealed he was nervous when Kohli was dropped by Azhar Ali for 5.”Everybody knows if you get Kohli, India is 50% out of the game. Until he is at the crease, India’s chances of winning are 70-80%. If you look at his chasing ratio, he is at the top of the world. He chases well, he performs well under pressure. So our plan was to get their top order – (Shikhar) Dhawan, (Rohit) Sharma, Kohli, the guys who were scoring the runs in the tournament,” Amir had told ESPNCricinfo in an interview.Also read – Shaheen Afridi stars as Pakistan beat Australia in T20I tri-seriesBut if you thought that was the most difficult thing Amir has had to, then there’s more.In a recent interview with Cricinfo, Amir, who has 213 international wickets, fatherhood is more difficult than bowling to Kohli.And for the record, while Kohli is Amir’s favourite batsman, he finds Steve Smith the most difficult batsman to bowl to.Kohli is leading India on a tour of England currently while Smith, who is serving a one-year ban over the ball-tampering scandal, is plying his trade in a T20 tournament Canada.advertisementKohli recently became the second Indian cricketer after Mithali Raj to reach 2000 T20 International runs. The India captain needed only eight runs before the start of India’s first T20I against England at Manchester on Tuesday.He became the quickest to get to the 2000-run mark in the shortest format. He took only 60 matches and 56 innings to enter the coveted club.He is also only the fourth male cricketer to reach the milestone after New Zealand’s Brendon McCullum and Martin Guptill and Pakistan’s Shoaib Malik.
FIFA president Gianni Infantino, in his visit to Kolkata two years ago, opined that the country is no longer ‘sleeping giants’.Arsenal and England legend Sol Campbell, witnessing the 2017 U-17 World Cup final at the Salt Lake stadium, said, Indian football has a bright future.The comments, otherwise music to ears, have a sense of ambiguity as they gloss over some serious facts.Just to jog the reader’s memory, India failed to win a single match out of their three group games held at the Jawaharlal Nehru stadium here, scored just one goal, courtesy Jeakson Singh Thounaojam, and were sent packing within six days of the competition.To put things into perspective, this national team’s performance was on the back of several foreign exposure tours, junior international tournaments and, not to forget, India had four years of preparation time.Now consider this: India has won the bid to host the FIFA U-17 Women’s World Cup next year. The country has no proper structure for women’s football, just one annual league across all age groups and only 11 states organise senior women’s tournament. The federation has selected 35 of the best players scouted at the Junior National Championship held in Kolhapur last month, a tournament which several players missed owing to school exams.In less than 18 months, players among these selected 35 will represent the country for the second time at a FIFA event but the stakes are higher this time around.Women’s football in India exists as oddly as the country’s presence at the international stage. The national team is ranked 63rd in the world, compared to men’s team lying 102nd, but that hardly gives an exact picture.advertisementOptimism is the word spread around the nation as the junior team starts preparation in Goa for the showpiece event in 2020. Just like their rankings, hopes remain high for the girls to outperform the boys from 2017.”The World Cup brings a lot of attention to the country. We will have many youngsters around and a lot of preparations will start from now. This will be the base for my senior team in 2-3 years time. They are a talented bunch and will have a good competition with the seniors,” senior women’s Maymol Rocky tells Mail Today.”As a coach, if you get time with the team you can do a lot of things, we def worked on their strength and fitness. The most important thing is, you make them understand that they should believe in themselves first,” she adds.The current lot of girls training in Goa is a bit different from the boys, who were preparing at the Tilak Maidan, couple of years ago.One of them, Drishti Pant, carries a badge of being the first and only player from Gujarat to be part of a World Cup probable squad.The 15-year-old was the star of the show when the state team reached the semi-finals of the Junior Nationals last month. And for her to be in the camp, considering Gujarat’s sad status at the national stage, speaks volumes of her talent.”I remember the time when I used to pick her up at 8.30 am from state camp because she had to appear for her exams. It seemed crazy that she was in training minutes before her exam but that’s the kind of dedication we had for her football career. It seemed like a dream when she told me she has been selected for the national camp. A World Cup is a huge thing and for her to be even in the probable squad is an achievement,” tells Hemant Pant, father of Drishti.It’s too early to predict the end product of what’s churning at the training ground in Goa. While the previous World Cup gave India improved stadiums and training facilities, hopes are the next one will improve the performance.Also Read | India set to host FIFA U-17 Women’s World Cup in 2020Also Read | Revamped FIFA Club World Cup important for Asia, says Gianni Infantino
New Delhi: The government has decided to demolish 400 old flats and construct new ones in their place in Lutyens’ Delhi for Members of Parliament using construction waste. The flats which will be coming up in North Avenue and South Avenue, located on either sides of the Rashtrapati Bhavan, will replace the old ones built nearly 60 years ago, officials of the Central Public Works Department (CPWD) said. “All old MP flats, which were built in North and South Avenues after Independence, will be demolished,” CPWD’s Director General Prabhakar Singh told PTI. Also Read – Cong may promise farm loan waiver in Haryana “We will use construction & demolition (C&D) waste in building the new flats for MPs in North and South Avenues, an area which has many old flats,” he added. The waste from the demolition site of the old flats are likely to be used for the construction of the new ones after being processed at a facility. CPWD, the prime construction agency of the central government, recently constructed 36 duplex flats, at a cost of Rs 80 crore, which are ready to be allotted for the newly-elected parliamentarians. Also Read – Modi formed OBC commission which earlier govts didn’t do: Shah “The new MP flats will be constructed in a phased manner in North Avenue and South Avenue so that there in no chaos after demolition of the old ones,” he said. The swanky low-rise buildings will have solar power panels and designated car parking spots, among a host of other facilities, the official said. The new Lok Sabha has around 300 first-time members, including cricketer-turned-politician Gautam Gambhir, Union ministers Ravi Shankar Prasad and Smriti Irani, Sufi singer Hans Raj Hans and Bengali actresses Mimi Chakraborty and Nusrat Jahan Ruhi. The government has made temporary arrangements to accommodate 350 MPs till the time they are allotted full-time official residences in Lutyens’ Delhi, an area in the national capital named after British architect Sir Edwin Lutyens, who was responsible for much of the architectural design and building of the high-security zone prior to Independence. In the past, newly-elected MPs used to stay in five-star hotels, but the practice has been dropped following the Lok Sabha Secretariat’s cost-cutting measures. The BJP-led NDA government started its second term as Prime Minister Narendra Modi and the other ministers of his council took the oath of office on May 30.
Winning Play$: Black Women, Feminism, & Empowerment was held Monday, June 26th 2017 at the Paley Center for Media in New York City.Winning Play$: Black Women, Feminism, & EmpowermentFinancial journalist, author and founder of the award-winning Winning Play$ financial education program Stacey Tisdale, along with an all-star panel, changed the conversation about black women from one of underdogs, to one of a story of resilience that all people, regardless of gender can learn from.Panelists for the evening included: Gloria Steinem, feminist icon, author, and activist; Carol Jenkins, award-winning journalist, writer, producer, and activist; Angela Yee, iheartmedia, Power 105.1 FM, and Breakfast Club host; Grace Vandecruze, Founder, and Managing Director, Grace Capital LLC; and Rianka Dorsainvil, President, and Founder of Your Greatest Contribution for Millennials. Tisdale served as moderator of the panel. Michelle Miller, CBS News Correspondent, was the mistress of ceremonies.Stacey Tisdale pointed out that despite the fact that black women only earn 64 cents for every dollar that white males make, black women have transcended socio economic limitations, and are the fastest growing group of entrepreneurs in the United States.Feminist icon Gloria Steinem stated that she learned about feminism from black women including such activists as Angela Davis and Alice Walker.Breakfast Club host Angela Yee noted that the modern day feminist movement needs to reflect the diversity of all women, including their social and economic positions.Other panelists, including Carol Jenkins, Grace Vandecruze, and Rianka Dorsainvil, touched on the ways in which immigrants and millennials experience the modern day feminist movement.Among the guests for the sold-out event was the legendary Susan Taylor, former editor-in-chief of Essencemagazine, and founder of the National CARES Mentoring Movement campaign aimed at empowering women and children of color.The event launched a national social media campaign in which Tisdale’s financial education program Winning Play$ will reach out to youth and communities around the country to empower them with financial skills and knowledge, building on the evening’s flexions of how black women have empowered themselves.Content from the event can be viewed beginning June 27 on Grio.com, which is owned by Entertainment Studios CEO Byron Allen and has an audience of over 11 million.The Grio, which means storyteller in Africa, is a digital video-centric news community platform providing compelling stories and perspectives. They focus on breaking news, opinion, entertainment, health, sports, business, politics and events that have an interest and/or pronounced impact within the African American community.“Conversations have the power to transform,” says Tisdale. The discussion these amazing women had will open minds, open hearts, and inspire millions of people at a time when far too many in the United States are focusing on our differences and perceived limitations. “This year Winning Play$ honored Justin Tuck, and his wife Lauran with the “Game Changers Award”, for their ongoing efforts to make young people financially literate through their R.U.S.H. For Literacy Foundation.There was also a special performance by the iconic alternative rock, and R&B trio BETTY.
MEXICO CITY — More than 25,000 Mexican workers at dozens of factories south of Brownsville, Texas, have gone on strike after owners of the plants that assemble for export refused union demands for a 20 per cent pay hike and an annual bonus.The government of Tamaulipas state says four of the 45 companies represented by the union reached terms to avoid strikes, while at least one announced plans to leave the city of Matamoros. Others halted expansion projects. The strikes took effect Friday afternoon. The factories make auto parts, medical equipment, plastics and other goods.The labour strife comes on the heels of President Andres Manuel Lopez Obrador’s promise to double the minimum wage just south of the U.S. border to 176.2 pesos a day, the equivalent of $9.28 at current exchange rates.The Associated Press
On the markets at midmorning (ET):The Toronto Stock Exchange’s S&P/TSX composite index was down 50.52 points to 15,114.84, after 90 minutes of trading.In New York, the Dow Jones industrial average fell 97.29 points to 21,532.43. The S&P 500 index shed 3.34 points to 2,455.80 and the Nasdaq composite index climbed 5.44 points to 6,319.87The Canadian dollar was trading at 79.21 cents US, up from Monday’s average price of 78.93 cents US.The August crude contract was up 44 cents to US$46.46 per barrel and the August natural gas contract was up six cents to US$3.08 per mmBTU.The August gold contract was up $7.30 to US$1,241.00 an ounce and the September copper contract was up one cent at US$2.73 a pound.
TORONTO — Canada is concerned that the political and economic turmoil in Venezuela will spark a refugee crisis for the South American country and its neighbours, Foreign Affairs Minister Chrystia Freeland said Monday.Freeland said that she and Peru’s foreign minister would take that message to the United Nations in New York City on Monday, following her appearance at a business conference in Toronto.Canada and Peru co-chaired a meeting of ministers from the Lima Group of countries last week in Toronto. Freeland and Peru’s foreign minister Ricardo Luna were delegated to meet with U.N. Secretary-General Antonio Guterres.Apart from Canada, the group’s 12 members are in Latin America.But Freeland said Monday that Venezuela and Canada are in the same geographic “neighbourhood” and that Canada has a role to play in supporting the country’s democratic institutions and respect for human rights.“I do think. . . this is a humanitarian crisis as well as a political one. We are seeing real preventable suffering of the people of Venezuela,” Freeland said at the Toronto Global Forum before heading to New York for the U.N. meeting.“And I think . . . there are mounting signs of a regional refugee crisis as well. Colombia and Brazil are facing a lot of pressure. So I think it is an area where Canada needs to be very engaged.”Venezuela — an oil-rich country that was led by outspoken socialist Hugo Chavez from 1999 to 2013 — has suffered an economic meltdown since his death.The dramatic drop in global oil prices since late 2014 and the devaluation of the country’s currency have fuelled triple-digit inflation that has resulted in shortages of food, medicine and other basic necessities.The government of President Nicolas Maduro, who succeeded Chavez, has also been accused of grabbing power by creating a new constitutional assembly that claims supreme authority over other arms of the government, including the opposition-controlled congress.In September, Freeland announced that Canada had imposed sanctions against 40 key figures in the Venezuelan regime, including Maduro, who she said had helped undermine the country’s stability.Freeland said Monday that support from allies would help pressure Venezuela further.“So I think it is an area where Canada needs to be very engaged. . . . We’d be delighted to see the EU joining us in applying pressure on the government of Venezuela,” Freeland said.Earlier in an on-stage interview by Frank McKenna, a former Liberal premier of New Brunswick and a former Canadian ambassador to the United States, Freeland acknowledged that the NAFTA trade talks have included some “troubling” proposals from the United States.Freeland specified two issues: the U.S. insistence of removing dispute-resolution measures contained in Chapter 19 of the North American Free Trade Agreement as well as its proposal to review the trade pact every five years.But she said the Canada-U.S. relationship is “robust and very deep” — noting the two countries are partners in the NATO and NORAD military alliances and that Canada is a bigger market for the United States than China, Japan and the United Kingdom combined.Freeland also said that barriers to trade under World Trade Organization rules have been reduced since NAFTA was signed by the United States, Canada and Mexico.“We looked at the actual trade — not the just the agreement but the actual trade that is happening — we found that around 40 per cent of Canadian exporters to the United States don’t use the NAFTA preferences that are available to them,” Freeland said.That suggests the differences between WTO and NAFTA rules have decreased and that administrative red-tape involved is a bigger barrier to trade than preferential tariffs in the three-country agreement, she said.“It’s very technical. Things like electronic forms at the border, things like regulatory harmonization,” Freeland said.“It really matters to Canadian and U.S. businesses and in most chapters (of the agreement) we’re going gangbusters in a very positive way.”
The suspect who was remanded in connection to the Thalawathugoda accident involving a BMW sports car, was granted bail today.The suspect, a relative of a United National Party (UNP) member and Minister, had fled the scene after his car plunged into the Diyawanna Oya in Thalawathugoda. The car had crashed into two vehicles before going into the Diyawanna Oya.The driver then fled the scene but surrendered to the Police and was arrested. (Colombo Gazette)
The minibus driver who was shot in his head following a robbery on the Mc Doom Public Road, East Bank Demerara this morning was pronounced dead at the Georgetown Public Hospital.38-year-old Tedroy James aka “Six-Head” of Essequibo Coast was the driver of a route 32 minibus.Based on information received, at around 11:30hrs today, James was traveling from Parika to Georgetown.One of his passengers- a male- reportedly asked to have the bus stopped along the public road. However, as he was about to exit the minibus, the man grabbed a bag belonging to another passenger before turning on him with a gun.The dead man’s cousin in white was inconsolable when she heard the news of his deathBy then, two other unknown males joined him and attempted to rob other passengers. The now dead minibus driver then attempted to drive away with the passengers but one of the three gunmen stopped him by shooting him once to the head.The trio then fled the scene through a street in the Mc Doom Village.At the hospital, relatives of James, who had gathered, erupted in frantic outbursts upon learning that their loved one had passed.Screaming and sobbing, James’ sister, Shondel James told Inews that he was her younger brother and she had last seen him earlier today, after traveling in his minibus to Georgetown.The distressed sibling noted that James has one other sister, and a brother who had passed before him.The dead man leaves to mourn two children.Investigations are ongoing. (Ramona Luthi) Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)RelatedUPDATE: One arrested for murder of bus driver at Mc DoomJuly 11, 2017In “Crime”McDoom robbery: Bagotstown mechanic remanded for bus driver’s murderJuly 18, 2017In “Court”Motorcyclist killed after minibus slams into himAugust 27, 2017In “Crime”
As the junior mining sector comes back into play – and on the back of the success of the 2017 Mining Indaba which, the organiser says, “saw more junior miners in attendance than any other event in Cape Town” – the organiser of the Investing in African Mining Indaba® is taking its commitment to the junior mining sector one step further with the introduction of the Junior Mining Showcase. The Junior Mining Showcase will provide a dedicated space in the exhibition area for 60 of the most promising junior mining companies currently involved in the exploration and development of African mineral assets. The Showcase will afford delegates the opportunity to meet with only investors, mining companies and other firms involved in deal making like banks and brokers, all in one place. “As investors rediscover that junior mining companies can deliver superior returns, particularly those who’ve survived the commodities down cycle, Mining Indaba is doing what it does best – bringing together the best in their fields to strike deals and secure investment,” says Alex Grose, Mining Indaba MD.This is an important and exciting addition to the 2018 program. The feedback received from the launch of the Investment Battlefield for junior miners in 2017 was overwhelmingly positive. Harry Chapman, Director of Content, says, “Our focus for 2017 was to bring the Mining Indaba back to its roots – a strategy that worked, with 71% more investors and 41% more mining companies in attendance. In 2018 we’re making the event more accessible for the junior players in the market.”VSA Capital, RFC Ambrian and Tamesis Partners LLP have partnered with the Mining Indaba on the Showcase. Andrew Monk, CEO at VSA explains, “VSA is very excited to be partnering with Mining Indaba in 2018 on the Junior Mining Showcase. We believe that the main Mining Indaba conference is where companies should be if they want to be part of an event that offers the ability to meet investors. Investors want to be at the main conference and we are delighted by the initiatives Mining Indaba are putting in place to ensure that even more investors attend. “Creating a dedicated area on the exhibition floor for junior miners as well as an innovative platform to pitch their stories is another step in making Mining Indaba the must go-to venue for junior miners. The Showcase is just a “meet and greet” proposition, it will have a principal focus on deal making and closing deals. This is Africa’s largest mining event – juniors can’t afford not to be part of it.”
gazprom handballRK VardarSEHASEHA GAZPROM HANDBALL After more than one year period Veselin Vujović, who has as a coach led Vardar to SEHA crown in League’s first season, will return to Skopje, this time in a role of PPD Zagreb’s coach. SEHA GSS League’s derby will, for the last time, be played in Kale sports hall (20:15 CET). Starting from the next week, Vardar will all of their home matches play in new ‘Jane Sandaski’ hall with capacity of over 5,000 seats.Both team have successful EHF Champions League’s weekends behind them. Vardar was with 26:27 better than Celje and Zagreb has managed to surprise one of Europe’s best teams Kiel and win 27:25. Interesting is also that both teams have one defeat in this SEHA GSS League’s season.Vardar’s coach Raul Gonzalez has not yet decided which players he will use on this match. He waits for the last training. Only thing that is sure is that Alexey Rastvorcev and Vladimir Petrić will have a seat in the crowd due to their injuries. Zagreb will miss Vuglač and Mandalinić who will both pause for seven more days. Team has arrived to Skopje after three victories in a row – two in regional League and one in CL.Raul Gonzalez, Vardar’s coach:– After a win in Celje two days ago in EHF’s Champions League but also a game in which we did not play well we have another tough match on our schedule. At the same time Zagreb has managed to beat Kiel, mostly because of their maginificent 5-1 defence which they are now playing under their new and Vardar’s former coach Veselin Vujović. This is an important match for us in which we want to win and get a step closer to our goal – SEHA GSS League’s Final Four.Veselin Vujović, PPD Zagreb’s coach:– This will be an emotional match for me. Vardar’s fans love me and I’m sure we’ll have a great atmosphere in the hall. Vardar has improved and reinforced much in last two seasons but our goal is to win. We have a young team which has made a big thing winning against Kiel on Sunday but we have to remain calm and use this match to improve our form. In my opinion we have 50:50 chances to win the match but I believe in my team and their good performance. ← Previous Story The new one from “Slovenian playmakers’ factory” – Miha Zarabec Next Story → EHF CL Round 1 – TOP 5 saves
Now Playing Up Next WhatsApp WALTER and Kassius Ohno set to compete at EVOLVE 135 and 136 Live Events Pinterest Recommended videosPowered by AnyClipBrexit’s Impact on Gilts, the Pound and the U.K. EconomyVideo Player is loading.Play VideoPauseUnmuteDuration 3:00/Current Time 0:04Loaded: 56.96%0:04Remaining Time -2:56 FullscreenUp NextThis is a modal window.Beginning of dialog window. Escape will cancel and close the window.TextColorWhiteBlackRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentBackgroundColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyOpaqueSemi-TransparentTransparentWindowColorBlackWhiteRedGreenBlueYellowMagentaCyanTransparencyTransparentSemi-TransparentOpaqueFont Size50%75%100%125%150%175%200%300%400%Text Edge StyleNoneRaisedDepressedUniformDropshadowFont FamilyProportional Sans-SerifMonospace Sans-SerifProportional SerifMonospace SerifCasualScriptSmall CapsReset restore all settings to the default valuesDoneClose Modal DialogEnd of dialog window.Replay the list Jamie Collins Comes Back To Gillette 9/13 NXT Live Results: Cocoa, FL (Dain vs. Kushida, NXT North American Title Match) Jakobi Meyers, Jarrett Stidham Shine As Patriots Crush Lions Now Playing Up Next Videos Articles Now Playing Up Next Twitter Brexit’s Impact on Gilts, the Pound and the U.K. Economy Patriots Make Trade As Tight End Situation Falls Into Rough Shape Google+ With his upcoming #NXTChampionship defense against @ProjectCiampa made official, what will @WWEAleister have to say NEXT WEEK on #WWENXT?! pic.twitter.com/YSRwTgGWWL— WWE Network (@WWENetwork) July 5, 2018 Now Playing Up Next Facebook Patriots Offense Shows Much Promise But Can Get Even Better As announced on this week’s episode of NXT, Oney Lorcan will be out for three months after undergoing surgery following NXT TakeOver: Chicago II.Lorcan suffered a broken orbital bone at TakeOver during the NXT Tag Team Championship match against The Undisputed Era a few weeks ago.Matches announced for next week’s episode of NXTThe following is set for next week’s episode of NXT:* NXT Champion Aleister Black to appear* Kairi Sane vs. Vanessa Borne* NXT North American Champion Adam Cole vs. Danny Burch* NXT Tag Team Championships Return Match: Moustache Mountain (c’s) vs. The Undisputed ERANEXT WEEK: @KairiSaneWWE goes one-on-one with @VanessaBorneWWE on #WWENXT, only on the award-winning @WWENetwork! pic.twitter.com/zobcieNKWd— WWE Network (@WWENetwork) July 5, 2018 Now Playing Up Next Jason Namako RELATED ARTICLESMORE FROM AUTHOR .@strongstylebrit had a pretty good idea earlier, and therefore next week it’ll be Danny Burch vs. Adam Cole.— William Regal (@RealKingRegal) July 5, 2018 Tom Keene NEXT WEEK: @roderickstrong & @KORcombat get their rematch for the #WWENXT #TagTeamChampionship when they challenge #MoustacheMountain @Tyler_Bate & @trentseven on @WWENetwork! pic.twitter.com/ExyiCv4hqD— WWE Network (@WWENetwork) July 5, 2018 NXT Highlights: Johnny Gargano addresses NXT future, Baszler vs. Ripley, Pete Dunne in action
However, most smaller publishers don’t have the war chest for six marketing acquisitions (or spending $350 million on a digital agency the way Hearst did for iCrossing). For them, entering marketing services requires a mix of in-house development and strategic partnering. Northstar Travel Media last month announced a marketing solutions division based around two internal staffers (a VP of marketing solutions in former TravelAge West publisher Michelle Rosenberg and a dedicated project manager), and a strategic tech partner in Decision Counsel to execute programs. The Northstar Marketing Solutions group will focus on five key areas of client support: technology platforms, events, research, creative services and social media management. “In the middle of last year, the executive team at Northstar looked at how we were handling marketing services within each individual brand,” says Rosenberg. “We found some synergies and opportunities to expand the range of services. That combined with investments we made in different assets—content, tech or research—allows us to look for cross-brand opportunities and delve into areas outside traditional media and marketing.” The Marketing Solutions Group has the potential to be a $2 million to $3 million business within two to three years, according to Rosenberg. Like Northstar, many publishers are taking services they’ve historically offered as standalones (custom publishing, Web site development, lead gen) to the next level under the umbrella of a dedicated group. While publishers can tap existing resources and brand-related salespeople can funnel prospects to marketing services, it’s a different enough business in terms of sales cycles, lead times and tech development that a separate approach is warranted. “Because it’s so heavily custom, we don’t walk in with a line card,” says Rosenberg “We say, here are our capabilities, what needs do you have? The biggest difference between pitching product advertising is a much longer cycle. These are complicated products.”Summit Media Group also debuted a new dedicated custom media group (“custom publishing” is increasingly becoming a description that marketers can’t relate to—hence the rise of “marketing solutions”) with seven full-time people and multiple freelancers. Summit is looking at an investment of several hundred thousand dollars “to move from where we are to where we want to be in the next six months to a year,” says vice president and group publisher Joe Angel. Summit takes a minimum quarterly retainer of $2,200 (which can go up to $7,000 or $8,000), but prices vary widely for its turnkey content creation services.Many of the services now falling under the umbrella of “marketing solutions” have previously been offered as value-added. “We need to change the nature of free with things like copywriting, consulting, white papers and surveys,” says Dave Newcorn, vice president of digital and custom media at Summit Media Group. “We charged one client $7,500 to put together a survey and send it. In any other kind of work, that’s consulting.” Summit came up with a price calculator that deducts hard costs but also incentivizes salespeople to sell high. Part of getting the new custom group off the ground was a “lunch & learn” campaign in which Newcorn and his group visited 108 customers in 15 cities, explaining the concept of lead nurturing. The publisher also did research identifying four stages of the buying process and what solutions to offer. They include: Stage 1: Status quo—No projects. Customers should be addressed with best practices and industry trends. Stage 2: Discovery—The customer knows they need a project but isn’t sure what to do. Here, white papers and Webinars are applicable. Stage 3: Vendor selection. Here Summit presents customer testimonials, assessment tools in which prospects can enter data and increasing use of video. “For our market, they want to see the machines in action,” says Newcorn. Stage 4: Short list. Vendor comparison charts. “Here, they need something downloadable,” says Newcorn. “A chart indicates they’re pretty far down the path. A boardroom PowerPoint is something junior execs can show to more senior, maybe less tech-savvy execs.”The Summit proposal package includes a kick-off meeting with the content creators, written analysis and recommendations and a 12-month road map. “Now that we have the infrastructure to produce custom packages, we have to look at how we sell it,” says Newcorn.With so many publishers competing with each other (and with agencies) over marketing services, real commitment from both management and staff is required. “I believe success will be defined by a commitment of resources and consistent commitment of the initiative from the top management of the organization,” says Northstar CEO Tom Kemp. Marketing services may be more successful in organizations that focus on specific sectors and have leadership brands within those sectors, Kemp notes. “Sector focus provides much more leverage of content, databases, domain expertise and relationships with major suppliers,” he adds. “Sector concentration may be a reason that the early success has been with publishers such as IDG, Hanley Wood, and UBM.”NetWorld Alliance has been doing custom publications for so long (at least 12 years) that they’ve become part of 70 percent of all client sales, according to president Tom Harper. “Special reports, case studies and white papers are part of our core business, whereas video, research and Web development are truly ‘custom’ for us because they require different people to deliver them,” he adds. “We are formally adding these new custom services after a year or so of testing them. And I don’t mean just testing their effectiveness for our clients—but determining whether we can handle the new types of projects with current staff, and finding out which outsources are reliable.”The publisher is looking to partner with an agency. “Our goal is to find a single agency we can trust who becomes a pseudo-division of our company without having to buy them out,” says Harper. “We have to be smart about partnerships and margins. When you’re our size, the outsource is the key to making the whole custom thing work.”Are Marketing Services Viable? At the ABM Annual Conference, Andy Goodenough, CEO of Summit Business Media and Scott Vaughan, chief marketing officer of UBM TechWeb, debated the viability of marketing services. Goodenough was representative of most of the b-to-b publishing world today—a company that’s seen dramatic changes to its business over the last few years (Summit Business Media just emerged from Chapter 11 bankruptcy) and is taking stock of where to go next.UBM TechWeb, on the other hand, has embraced marketing services and undergone a major internal shift to provide those services.According to Goodenough, the original model for marketing services included these things:• Sell advertising• Track bingo card responses• Offer up surveys• List rental• PR opportunities• Reprint services• Ad Plaques• Sponsored supplementsAnd all the while, the sales executive is the principal entry point into the advertiser relationship. Now, however, the new model looks like this:• Digital advertising• Print advertising• Events• Webinars• Lead tracking• Research• Marketing data• E-mail messages• Custom marketingAnd the sales executive is still the principal entry point to the marketer relationship. “The new model,” Goodenough said, “looks a lot like the old model, except that the products are a little different.” Going forward, a key question is this, Goodenough said: “Are we media companies or marketing services agencies, and is there an orderly progression?”In his case study, Vaughan described his approach, which he calls “Marketing-as-a-Service.” In b-to-b media, he said, marketers now have a whole new array of ways to listen, engage and connect, and the challenge for media companies is to align with these shifts. Marketers expect performance with guaranteed metrics, he said. They want deeper integration of their media spend with ROI and revenue. They want a single point of accountability and they want expertise and efficiency.In 2011 and beyond, Vaughan said, b-to-b means no longer chasing customers and moving toward creating the next customer. Equally important, he said, is that media companies need to understand that it’s not about their own cool internal innovation, but rather, “what business my customers demand me to be in?”The way UBM TechWeb handles it, he said, is by looking at its business as two distinct units. The business information unit fuels insights into technology decision making. This includes education and conferences, research and analytics, Web sites, newsletters, magazines and the like. Marketing-as-a-service plays off the strength of the business information side and offers content development, communities, lead services and performance marketing. It guides buyers through a lead lifecycle and quantifies who makes which decisions. MaaS, Vaughan said, is not custom publishing, it’s not custom media, and it’s not integrated marketing. Instead, it’s a cluster of services built around four service areas and four distinct platforms. “For a fee, we’ll make your content perform better,” Vaughan said. “We call it MaaS because it keeps us focused on what business we’re in.”SIDEBARThe Return of ContentContent creation, long viewed as a cost center within traditional publishing, took some hard lumps in recent years, as the means of paying for that content—advertising dollars—eroded. The early days of digital media weren’t any better, as media companies quickly realized the revenue online just wasn’t enough to pay for content creation on any real scale. Aggregation, social media, user-generated content and licensing were looked at as ways to fill the content gap without breaking the bank (and still are). However, the rise of marketing services has made publishers once again realize the need for original, quality content—both in serving marketing clients and attracting those clients in the first place through the publisher’s core brands. “What’s interesting is [clients] want our expertise as content producers, not our audience,” says Dave Newcorn, vice president of digital and custom media at Summit Media.While publishers scramble to hire salespeople with an agency understanding of account management, agencies are looking for content experts. “You can’t have a social strategy without a content strategy,” says Tom Stein, president and founder of b-to-b agency Stein Rogan + Partners. “You can’t have a CRM strategy without a content strategy. Some days in my agency I feel as much like an editor as anything else.” American Business Media’s Annual Meeting, held in early May, took a single theme approach around the topic of marketing services. While the core of marketing services is based on many things publishers already offer (content, data, lead gen), it’s also a different business with longer sales cycles, sometimes lower margins, and a different sales and editorial mentality. It’s the latest example of publishers “chasing new money in a hurry,” according to Mitch Rouda, president of e-media at Farm Journal Media. But publishers need to be wary of not just chasing yet another “answer” to the problem of crumbling traditional revenue models. In response to a FOLIO: article about content marketing last month [“The Content Marketing Revolution,” April 2011], Dan O’Connell president of agency Foodmix Marketing Communications said, “Publishers entering the agency world happens every decade with a different spin. It failed in the 80s, 90s and it will again. Why enter a business you don’t understand when your core business is bleeding? Wouldn’t a more powerful combination be for agencies and publishers to partner to meet the evolving needs of advertisers and their brands?”Entering the Marketing Services WorldFor some publishers, acquiring their way into marketing services (in March, Penton bought online marketing firm EyeTraffic Media) may be the best option. Referencing the development of Meredith Integrated Marketing, Tom Stein, president and founder of b-to-b agency Stein Rogan + Partners, said it was based on six acquisitions and that former Meredith National Media group president Jack Griffin told him, “If we decided to do this in-house, we’d still be just talking about it.”
Mancherial: High Tech City committee members and Surabhi Ravi on Wednesday felicitated Municipal vice-chairman Nalla Shankar for his service towards urban development for the past five years. They also felicitated ward 3 councillor Edla Lalitha Shankar on the occasion.Speaking on the occasion, Shankar thanked municipal authorities, without whose contribution and cooperation it was not possible to develop 32 wards. High Tech City committee president Surabhi Ravi said counsellor Edla Lalitha Shankar had developed electric lamps, sewers and roads. Munnuru Kapu Sangham district president Nallakotamma felicitated Nalla Shankar with a shawl. Sanjeev Vemula, Satyam, Khaja Pasha and colony people were present on the occasion.
Top executives at India’s second largest IT firm, Infosys, saw their compensation packages rise by a whopping 170-210% in FY15, however, CEO Vishal Sikka is not the highest paid in the company.The compensation details submitted by Infosys to US Securities and Exchange Commission showed that Chief Operating Officer UB Pravin Rao was the highest paid top executive in the company during the fiscal year 2014-15, The Financial Express reported.Rao, who took over as COO of Infosys in June 2014, saw a 204% increase in his total compensation standing at $9,70,646 or ₹5.82 crore compared to the $3,18,954 he received in FY14.Since joining Infosys in 1986, Rao has held a number of senior leadership roles in the company.Same is the case with Rajiv Bansal, the chief financial officer, whose total compensation rose by 174% in FY15. Bansal was the second highest paid executive in the company.Srikantan Moorthy, who was the head of HR department until recently, also received a 211% increase in his compensation to $6,42,628 in FY15 compared to $2,06,958 in FY15.However, the compensation of CEO Sikka stood at $7,16,539 or ₹4.3 crore, less than that of COO’s, as he did not receive any bonus or incentive in the financial year ending March 2015.Sikka, the first non-founder head of the company, took charge as the chief executive of the company from 1 August 2014.Rise in compensation for top executives comes in the wake of many senior-level executives leaving the company in the past two fiscal years. However, the attrition rate came under check after Sikka got appointed as CEO.The Bengaluru-based company recently announced an average salary hike of 6.5% as it faces the highest attrition rate among domestic IT firms.While announcing its results for March quarter, CEO Sikka said the company aims at boosting revenues to $20 billion from current $8.7 billion over the next five years.
Attorney general Mahbubey AlamAttorney general Mahbubey Alam on Tuesday said the review petition against the Supreme Court verdict on the 16th amendment of the constitution will be filed in December, reports UNB.”We found the certified copy of the Appellate Division verdict that scrapped the 16th amendment of the constitution on Monday. So, we have 28 days more time in hand. I hope, we will file the review in December,” Alam told journalists at his office.Mentioning that there is no benefit to lodge the review petition right now, he said, “Seven justices of the Appellate Division heard the main appeal. Now, the number of justices is five in the Appellate Division. As per the rules of the review petition, either equal number or more justices are needed to hear the review petition.”There is no possibility of hearing until new justices are appointed at the Appellate Division.On 4 November, law minister Anisul Huq said the review petition would be filed within this month.On 1 August, the Supreme Court released the full text of its verdict upholding the High Court verdict that declared illegal the 16th amendment to the constitution establishing parliament’s authority to remove Supreme Court judges.The Jatiya Sangsad passed the 16th amendment on 17 September 2014.On 5 May last year, the HC declared the 16th amendment illegal. The government on 4 January last filed an appeal with the apex court challenging the HC decision.On 3 July, the Appellate Division, led by chief justice Surendra Kumar Sinha, upheld the HC verdict.
Five new members were appointed to Morgan State University’s Board of Regents and two were reappointed recently. The Board, which sets admission standards, reviews and approves university policies and budgets is made up of 15 people who are appointed to five-year terms by Maryland Governor Larry Hogan. The appointments must be approved by the legislature when it goes back into session in January.The board members who were replaced were Franklin Edmonds, retired senior vice president, Xerox Supplies Business Group; former Maryland State Senator Laurence Levitan, partner, Rifkin, Weiner, Livingston, Levitan & Silver; Dallas Evans, managing director, Landmark Atlantic; Eleanor M. Carey, partner, Synergies Consulting Group. All except for Carey were long-standing members.The student representative, who serves for one year and is known as the student regent, was also replaced. Sarai Nwagbaraocho takes the place of Latichia Perine.The new board members are Tracey L. Parker-Warren, administrative law judge, Office of Administrative Hearings; Marquis T. Walker, post-doctoral fellow, The Johns Hopkins School of Medicine; Shelonda Stokes, president and CEO, greiBO media; Winston A. Wilkinson, chief of staff, Maryland Governor’s Office of Community Initiatives. Parker-Warren and Wilkinson were named on Oct. 23 while Walker and Stokes were named on Nov. 3. The appointments are retroactive to July 1. All of the new board members are Morgan grads.Dr. Shirley Malcom, head of The Directorate for Education and Human Resources Programs, American Association for the Advancement of Science and Dr. Linda Gilliam, chairperson of the board of directors, Gilliam Foundation were both reappointed.Other notable board members include: Rep. Elijah Cummings (D-MD); Rev. Frances “Toni” Draper, pastor of Freedom Temple AME Zion Church, vice chair of the Morgan board; Tyrone Taborn, publisher, chairman and CEO of Career Communications Group; Larry Ellis, four star general, U.S. Army (ret.). Former Congressman and President and CEO of the NAACP Kweisi Mfume is the chairman of the board.In a statement to the AFRO, Mfume said, “I am pleased to welcome the new board appointees and very much look forward to working with them.”
Already facing several charges including wire fraud and bribery, embattled Baltimore Sen. Nathaniel Oaks (D-41), is facing additional federal charges. According to the U.S. Attorney for the District of Maryland, a federal grand jury returned an indictment Nov. 15, charging Oaks, 71, with obstruction of justice.In this Feb. 6, 2009 photo, Maryland Del. Nathaniel T. Oaks, , Democrat, District 41, Baltimore City, glances toward fellow delegates as he questions then Baltimore Mayor Sheila Dixon during a hearing in the House of Delegates, Baltimore Delegation, in Annapolis, Md. Oaks, who used the word “lollipop” as a code word for every $1,000 he expected to be paid has been charged with accepting illegal payments in exchange for using his position to facilitate business deals, the U.S attorney’s office announced Friday, April 7, 2017. (Glenn Fawcett /The Baltimore Sun via AP)According to the U.S. Attorney’s Office, Oaks agreed to cooperate in an FBI investigation for possible violation of federal laws. Oaks was directed by the FBI to record phone conversations and wear a hidden recording device during in-person conversations with the specific target of the investigation. The conversations between Oaks and the target of the FBI investigation allegedly took place between January 2017 and March 2017.However, according to federal officials Oaks tipped off the target of the investigation at an Annapolis bar when Oaks allegedly said, “What we talked about, just say no.” The indictment also alleges Oaks told the target of the investigation, “I’m going to ask you for something, just say no,” during a conversation at a State government building in Annapolis. Both conversations allegedly took place in March 2017.According to the original indictment, Oaks, who was appointed to the Senate in February 2017, committed fraud and took more than $15,000 in bribes in 2015 and 2016. Oaks faces a maximum sentence of 20 years in prison for each count of wire fraud and honest services wire fraud, and five years in prison for each count of the Travel Act. He also faces 20 years in prison for the latest charge of obstruction of justice. An appearance for Oaks on the obstruction of justice charge has not been scheduled yet.
More information: Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord, Scientific Reports (2015) 5:8514, doi:10.1038/srep08514 Citation: Tomorrow’s tomography today: Simultaneous 3D imaging of vascular and neuronal networks in mouse spinal cord tissue (2015, March 6) retrieved 18 August 2019 from https://phys.org/news/2015-03-tomorrow-tomography-today-simultaneous-3d.html Exploring X-ray phase tomography with synchrotron radiation This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Dr. Alessia Cedola discussed the paper that she, Dr. Michela Fratini and their co-authors published in Scientific Reports. The scientists had to address two related challenges, Cedola tells Phys.org, these being (1) showing that X-ray high-resolution phase-contrast tomography allows the simultaneous visualization of three-dimensional vascular and neuronal networks of ex vivo mouse spinal cord at scales spanning from millimeters to hundreds of nanometers without using contrast agent, sectioning, or destructive sample preparation; and (2) imaging single elements of these networks, such as microcapillaries and micrometric nerve fibers, axon-bundles and neuron soma. “Due to its potential ability to reveal the structures that generate poor contrast by common x-ray absorption techniques, we used SXrPCμT to simultaneously obtain 3D images of microvascularization and spinal cord neurology in a healthy mouse,” she explains. In fact, she notes that SXrPCμT is roughly 1,000 more sensitive to hydrogen, carbon, nitrogen, and oxygen than absorption-contrast X-ray imaging – and moreover has several additional advantages derived from its ability to provide high-resolution images that allow 3D reconstruction without damaging tissue samples.Cedola points out that better contrast can be achieved by imaging the phase modulation induced by an object in a coherent or partially coherent beam. “Different techniques have been developed to exploit phase contrast in the X-ray regime. A simple yet effective phase contrast method for hard X-rays is based upon inline imaging after free space propagation: When synchrotron X-rays illuminate the sample, variations in optical path length produce slight local deviations of the X-ray beam. In absorption radiography the detector is generally placed close enough to the sample that these variations are unnoticed – but on the contrary, when a free space propagation distance is allowed between sample and detector, the recorded image contains the information on the sample structure in the form of a pattern of interference fringes. Therefore, specific algorithms have to be used to retrieve from this pattern the morphological distribution of absorption and phase within the object.””This makes it possible image spinal cord microarchitecture and its 3D distribution – a hopeless task with conventional X-ray techniques,” Cedola continues. “In particular, the results reported in our paper are unique in that they simultaneously provide a detailed three-dimensional analysis of the microvascular network,” or μVN, “as well as the relevant interactions with neural cells in the healthy mouse’s spinal cord – and to do so without any contrast agent. Our resolution allows us to discriminate the smallest capillaries and neuronal morphology with neither invasive contrast agents nor aggressive sample preparations, thus minimizing the possibility of data misinterpretation.” The scientists then compare these results with conventional histological sections of the same sample and region. In order to unequivocally identify the microvascular network, similar samples are measured with and without a prepared contrast agent called Microfill – a lead-containing radiopaque (that is, opaque to X-rays or similar radiation) silicone rubber. When the contrast agent is not used, the μVN can be imaged with great accuracy, which in turn lets the researchers investigate its spatial distribution. Journal information: Scientific Reports (Phys.org)—Given that blood supply to the brain and spinal cord is fundamental to central nervous system (CNS) physiology and pathology, it’s not surprising that trauma and disease in spinal cord blood vessels and neurons lead to a range of neurodegenerative pathologies and other serious consequences. However, current imaging tools do not generate sufficient dimensionality, resolution, contrast and other factors critical to investigating neurodegenerative pathologies and spinal-cord-injuries, as well as to understanding the relationship between vascular and neuronal systems. Neural population investigation: a) White/grey matter interface, imaged with inverted color, of a thick slab selected in the anterior horn of the lumbar-sacral spinal cord. b) Nissl staining, c) Hematoxylin/eosin staining and d) Immunohistochemical analysis of SMI-32, a marker of motor neurons, at the white/grey matter interface of the anterior horn of the lumbar-sacral spinal cord. e) Magnification of a single neuronal cell. Zoom of image f) SMI-32 labeled cells and g) hematoxylin/eosin staining showing a single neuronal cell. Credit: Fratini, M. et al. Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord. Sci. Rep. 5, 8514; DOI:10.1038/srep08514 (2015). Copyright © 2015, Rights Managed by Nature Publishing Group. Licensed under CC BY 4.0. a) X-ray Phase Contrast Tomography reconstructed volume of 1.2 mm thick of the lumbar-sacral region of the spinal cord. The image is obtained at a spatial resolution of 0.64 mm without contrast agent at TOMCAT beamline. The inset is a sketch of the imaged volume of the spinal cord. b) Nissl staining of the lumbar-sacral spinal cord. c) Immunohistochemical analysis of SMI-32, a marker of motor neurons, in the lumbar-sacral region of the spinal cord. d) Detail of the radial vessels of one of the vascular tree penetrating the gray matter. e) Immunohistochemistry of laminin, a marker of blood vessels, in the anterior portion of the lumbar-sacral spinal cord obtained at different levels. The red arrows in a) and b) indicate the central spinal cord canal. Credit: Fratini, M. et al. Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord. Sci. Rep. 5, 8514; DOI:10.1038/srep08514 (2015). Copyright © 2015, Rights Managed by Nature Publishing Group. Licensed under CC BY 4.0. Specifically,Micrometric-scale imaging of brain tissue such as Scanning Electron Microscopy (SEM) provide 2D images of neurons or vessels, and moreover require invasive sample preparationPost-mortem techniques also use SEM, but cannot be used to perform quantitative analyses Two-photon microscopy and other more recently-introduced methods provide 3D information but have limited penetration depth and target area sizeMagnetic Resonance Imaging (MRI) or Positron Emission Tomography (PET) allow for both structural and functional imaging, but cannot investigate microvascular networks due to spatial resolution limitationsMR angiography and volumetric-computed tomography are robust 3D imaging techniques but cannot visualize small vessels Conventional X-ray angiography also has a detection limit preventing it from imaging micrometric vessels and capillariesHigh-resolution X-ray synchrotron phase contrast tomography (XSPCT) can achieve 3D imaging of microvascular networks, but to date has required a contrast agent to visualize both microcapillaries and neuron morphologyHowever, in a recent interdisciplinary multisite study conducted at the Italian National Research Council, Enrico Fermi Centre, and other sites in Italy; European Synchrotron Radiation Facility, France; Paul Scherrer Institut, Switzerland; and other research facilities, scientists demonstrated that Synchrotron X-Ray Phase Contrast Microtomography (SXrPCμT) – a combination of high-resolution X-ray Phase Contrast Tomography and the coherence of a Synchrotron X-ray source – achieves high image contrast and enables high-resolution 3D visualization of ex vivo mouse spinal cord microvascular and neuronal in the same image. (Synchrotron X-ray tomography employs phase contrast imaging to exploit a difference in the refractive index between a detail and its surroundings, which causes a phase shift between the light that travels through the sample; ex vivo refers to experimentation or measurements done in or on tissue from an organism in an external environment with the minimum alteration of natural conditions.) Moreover, SXrPCμT accomplishes this without contrast agents (thereby increasing accuracy), sectioning or destructive sample-preparation. In addition to CNS disorders and traumatic spinal cord injuries, the researchers say that their experimental approach has significant potential in the investigation of a large number of ex vivo pre-clinical studies; might benefit biomedical, pre-clinical and clinical applications; and, perhaps unexpectedly, can be applied to the study of cultural heritage, where applications could include multiscale 3D imaging of morphology of fossils, opaque amber, prehistoric bones, and the virtual unrolling of unpublished ancient fragile papyrus writings. “Thanks to the collaboration between CNR, Centro Fermi and European advanced synchrotron radiation facilities, like ID 17 at ESRF (France) and Tomcat at PSI (Switzerland), it was possible to obtain high-quality phase contrast images,” Cedola says, adding that the use of advanced techniques with synchrotron X-rays was complemented by state-of-the-art image reconstruction algorithms. “Our work focuses on an interdisciplinary research,” Cedola tells Phys.org. “We engage biomedical science and physics with the intent to focus on the translation of modern X-ray physics concepts to pre-clinical applications. In addition, we believe that our paper demonstrates the potentialities of the synchrotron X-ray phase contrast microtomography technique, showing that it can be applied to a large number of ex vivo pre-clinical studies.”In their paper, the scientists describe their approach as being very well-suited for pre-clinical investigation of neurodegenerative pathologies and spinal-cord-injuries. “Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis, and Huntington’s disease, represent a most prevalent health problem worldwide,” Cedola notes. “The main goal of this project is to develop a solid method for pre-clinical research in this field,” pointing out that there is growing interest in high-resolution imaging techniques for the investigation of several pathological markers. “Our framework allows for a direct, quantitative estimation of the most important morphological and topological parameters characterizing the vascular and neuronal networks in the spinal cord. In particular, the 3D spinal cord geometry obtained using SXrPCμT will provide an innovative framework aiding the regular application in the pre-clinical practice to, for example, select the best treatment.”The paper also addresses the various ways in which their approach can be applied to resolve the entangled relationship between vascular and neuronal systems. “Neurons, astrocytes, glia, and microvessels seem to constitute an integrated functional unit, whose primary purpose is to maintain the homeostasis of the brain’s microenvironment,” Cedola says. “Furthermore, it was found that alterations of the CNS vascular regulatory mechanisms lead to brain dysfunction and diseases, including cancer, ischemia” – in which insufficient blood flow to the brain leads to cerebral hypoxia (insufficient oxygen supply) and, in turn, neuronal cell death or stroke – “edema, damage to white matter, and other neurodegenerative pathologies. Thanks to these high-resolution techniques making it possible to simultaneously visualize the distribution and interactions of vascular and neuronal networks in various tissue types, we may finally resolve the relationship between the microvascular and neuronal systems. This promises significant progress in understanding the neuronal and vascular physiology of neurodegenerative diseases, leading advances in regenerative medicine for the treatment of traumatic spinal cord diseases.”Moving forward, Cedola tells Phys.org that the study of central nervous system disorders and traumatic spinal cord injuries are the most significant examples of the next steps we plan to take in our research. “In addition,” she continues, “the study of the spinal cord system can be of immediate and fruitful application in the medical field and in particular in the investigation and treatment of neuro-degenerative diseases, such as multiple sclerosis, and spinal cord injuries. Recently, for example,” she illustrates, “traumatic diseases of the spinal cord have been treated with regeneration methods, making evident the utility of a tool able to verify the effectiveness of treatments during the testing phase.”Looking further into the future, when asked how their research might contribute to the effort to create an integrated structural/function connectome of the entire brain, Cedola replies that “the possibility to obtain 3D quantification of the vascular and neural networks and, by means of their characteristic and real geometry using SXrPCμT and specific algorithms, will be employed to refine current vascular and neuronal models. “That said, while we’re not directly involved with efforts such as the NIH Human Connectome Project or the Harvard/MGH-UCLA consortium Human Connectome Project, we’ve used their data and collaborate with several of their members.” © 2015 Phys.org VN investigation: a) X-ray Phase Contrast Tomography reconstructed volume of lumbar-sacral region of the spinal cord. The image, obtained with a pixel size of 0.64 mm without contrast agent at TOMCAT beamline, was segmented to show the capillaries and the nerve fibers. b) Magnified region of a): the vessels are red and the nerve fibers are green. c) Immunohistochemical analysis of laminin, a marker of blood vessels, in the lumbar-sacral spinal cord showing a coronal section of the vascular system. d) Immunohistochemical analysis of myelin basic protein (MBP), a marker of the myelin sheath of nerve fibers in the spinal cord. Credit: Fratini, M. et al. Simultaneous submicrometric 3D imaging of the micro-vascular network and the neuronal system in a mouse spinal cord. Sci. Rep. 5, 8514; DOI:10.1038/srep08514 (2015). Copyright © 2015, Rights Managed by Nature Publishing Group. Licensed under CC BY 4.0. Explore further